PRP-C18

Oligonucleotide HPLC

PRP-C18 columns have genuine pH and chemical stability. The stationary phase stands up to prolonged exposure to concentrations as high as 1 M NaOH and 1 M H2SO4, with no measurable decrease in performance. The support does not strip, bleed, or dissolve at any pH. It can therefore perform reliably and reproducibly throughout the extended life of the column, regardless of mobile phase conditions. Unlike a silica C18 column, the PRP-C18 is resistant to temperatures above 100°C.


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PRP-C18 Overview

High efficiency separations at any pH

The Hamilton PRP-C18 is a new HPLC column designed to provide high-efficiency, reversed-phase separations over an extended column life in nearly any mobile phase or pH. The rigid stationary phase has excellent mechanical and thermal stability (> 100°C), does not shrink or swell, and is completely inert to most conditions commonly encountered in reversed-phase chromatography. The PRP-C18 is a durable and effective column for general purpose HPLC and especially well-suited for specialized applications in the clinical, pharmaceutical, environmental, food, forensics, and life sciences industries. For additional information, please refer to the PRP-C18 Product Datasheet.

PRP-C18 Columns

The Hamilton PRP-C18 is a new HPLC column designed to provide high-efficiency, reversed-phase separations over an extended column life in nearly any mobile phase or pH. The rigid stationary phase has excellent mechanical and thermal stability (> 100°C), does not shrink or swell, and is completely inert to most conditions commonly encountered in reversed-phase chromatography.
HPLC

PRP-C18 Guard Columns

Guard columns can provide many benefits when used upstream from an analytical, preparative, or semi-preparative column. Guard columns are typically chosen to have the same packing as the primary column.
PRP-C18 Guard Columns

PRP-C18 Bulk Resin

Hamilton chromatography resins can be ordered in bulk, i.e., not packed into column hardware. This is a low-cost approach to application-specific testing and analyses.
PRP-C18 Bulk Resin

Tech Center

Choosing Column Specifications
HPLC Column Care & Troubleshooting
HPLC Resin Specifications
HPLC Guard Cartridge Holder Assembly - PEEK
HPLC Guard Cartridge Holder Assembly - Stainless Steel
Safety Data Sheets

PRP-C18 Resources

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

Fast HPLC Analysis of Dyes in Foods and Beverages

Application Note

Fast HPLC Analysis of Dyes in Foods and Beverages (PRP-C18)

Despite the growing evidence that artificial dyes are harming people, the FDA has allowed synthetic dyes' continued use. Read our app note on a quick identification method using reversed-phase HPLC (PRP-C18).
THC Metabolites in Urine

Application Note

THC Metabolites in Urine (PRP-C18)

In humans, cytochrome P450 contains three primary enzymes involved in the metabolism of Δ9-tetrahydrocannabinol (CYP2C9, CYP2C19, CYP3A4). These enzymes are mostly found in the liver, but can occur in other lipophilic tissues like brain, small intestine, heart, and lungs.
The Heat is On: The Isolation of Capsaicin for Therapeutic Treatments

Application Note

The Heat is On: The Isolation of Capsaicin for Therapeutic Treatments (PRP-C18)

A comprehensive investigation of the isolation of capsaicin for therapeutic treatments.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

laboratory solutions

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Hamilton Scale-up Liquid Chromatography

cation exchange column

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USP "L" Column Listings

Explore Hamilton’s qualifying USP “L” columns.

Browse app notes, user guides, specification documents, and more in our Knowledge Center.

HPLC FAQ

FAQ

How Do I Connect a Stainless Steel Guard Cartridge to my HPLC Column?

The process of connecting a guard cartridge to an HPLC column is fairly simple, but requires different steps based on the HPLC instrument and the guard cartridge configuration. Click to read our step-by-step guide.
HPLC FAQ

FAQ

How Do I Connect a Stainless Steel Guard Column to My HPLC Column?

Connecting a guard column to an HPLC column is straightforward, but requires different steps based on the HPLC instrument and its configuration. Click the headline above to read this step-by-step guide.
HPLC FAQ

FAQ

How Do I Connect a PEEK Guard Cartridge to my HPLC Column?

The process of connecting a guard cartridge to a HPLC column is straightforward, but requires different steps based on the HPLC instrument and its configuration. Click the headline above to read this step-by-step guide.
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